Epson printers have a built-in, permanent printhead. While this allows Epson to use a very high quality printhead, anyone who has replaced the printhead after warranty found out real quick that a new printhead cost more than a new printer!
Whether you use original Epson cartridges or compatible Epson cartridges, there WILL come a day when a few or even many nozzles will be blocked and the cleaning cycles will not solve the problem. It is not whether it will happen, but most likely when. I had to return my last Epson printer, an Epson Stylus Color 800, 3 times during the 1 year warranty. That was the last Epson I will ever own. I would hazard to say that each year Epson printers seem to get more finicky. Higher resolution (smaller nozzles), faster printing (faster drying inks) and longer cleaning cycles are a recipe for failure. It is important to understand the problem and why it happens.
Symptoms:
You just put in a new cartridge and a few nozzles are missing. You run several cleanings, no improvement, or more times than not, the problem is worse ... even more nozzles are missing or the whole color is gone! Don't blame the cartridge, it is just a box of ink and unless the manufacturer has used the wrong ink (which is very unlikely these days) then you have just been introduced to the number 1 problem for Epson printer owners.
After 8 or 10 cleans, like a miracle, it starts to print properly ... or you put in another new cartridge (possibly breaking down and actually buying an expensive, original Epson cartridge) and low and behold there it is printing perfectly! Unfortunately the next morning the problem is even worse than it was! How can this be? Now I've got to run several cleanings every time I want to print and sometimes even this doesn't help. Now my ink cartridges last half as long. It's just got to be poor quality cartridges?!
And don't forget, 8 or 10 cleanings can use half the ink in the cartridge so you will definitely get fewer pages from a cartridge if you run many cleanings. Virtually all compatible cartridges contain at least as much ink as an original; in some cases more.
The above scenario can happen at any time, but it most often happens when changing a cartridge or if the printer has not been used for an extended period of time. If it takes you six months or more to go through a set of cartridges, your chances of the problem described above is several times more likely than those who use their printer daily.